Article
FLT3 as a therapeutic target in childhood acute leukemia.
Current drug targets - 1 Jun 2007
Stubbs Matthew C, Armstrong Scott A
Abstract excerpt
During the past few years, a major focus of leukemia research has centered on tyrosine kinases as potential therapeutic targets. This is due in large part to the success of imatinib mesylate (STI571, Gleevec), which has proven effective as a therapy for chronic myeloid leukemias bearing the t(9;22) encoding the BCR-ABL kinase. It has become increasingly evident that mutations producing constitutively active...
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