Article
RET-mediated autophagy suppression as targetable co-dependence in acute myeloid leukemia.
Leukemia - 1 Oct 2018
Rudat S, Pfaus A, Cheng Y Y, Holtmann J, Ellegast J M, Bühler C, Marcantonio D Di, Martinez E, Göllner S, Wickenhauser C, Müller-Tidow C, Lutz C, Bullinger L, Milsom M D, Sykes S M, Fröhling S, Scholl C
Abstract excerpt
Many cases of AML are associated with mutational activation of receptor tyrosine kinases (RTKs) such as FLT3. However, RTK inhibitors have limited clinical efficacy as single agents, indicating that AML is driven by concomitant activation of different signaling molecules. We used a functional genomic approach to identify RET, encoding an RTK, as an essential gene in multiple subtypes of AML, and observed that AML...
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