Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GAB2 is a novel target of 11q amplification in AML/MDS

1 Jan 2006

Abstract excerpt

Chromosome arm 11q amplifications involving the mixed lineage leukemia gene (MLL) locus are rare but recurrent aberrations in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). We have recently shown that in addition to the MLL core amplicon, independent sequences in 11q23-24 and/or 11q13.5 are coamplified within the same cytogenetic markers in 90% and 60% of patients, respectively. Here we further...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Chronic Lymphocytic Leukemia Research
Share to Protein Degradation and Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16736498
DOI: 10.1002/gcc.20344

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

GAB2 is a novel target of 11q amplification in AML/MDSPMID 16736498Read ↗

GAB2 couples genetic drivers and signaling networks in acute myeloid leukemia.Semantic proximity Read ↗

Gab2 deficiency prevents Flt3-ITD driven acute myeloid leukemia in vivo.Semantic proximity Read ↗

Overexpression of the signaling coordinator GAB2 can play an important role in acute myeloid leukemia progression.Semantic proximity Read ↗

A role for the scaffolding adapter GAB2 in breast cancer.Semantic proximity Read ↗

Expression analyses identify MLL as a prominent target of 11q23 amplification and support an etiologic role for MLL gain of function in myeloid malignanciesSemantic proximity Read ↗

Acute Mixed Lineage Leukemia With an inv(8)(p11q13) Resulting in Fusion of the Genes for MOZ and TIF2Semantic proximity Read ↗

Gab2 promotes hematopoietic stem cell maintenance and self-renewal synergistically with STAT5.Semantic proximity Read ↗

MLL amplification in myeloid leukemias: A study of 14 cases with multiple copies of 11q23Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.