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Article

A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival.

British journal of haematology - 1 Jul 2009

Masson Kristina, Liu Tao, Khan Rasheed, Sun Jianmin, Rönnstrand Lars

Abstract excerpt

The haematopoietic growth factor receptor Flt3 has been implicated as major cause of transformation in acute myeloid leukaemia. Intracellular signals mediated by wild-type Flt3 are involved in cell differentiation and survival whereas signalling via the mutant Flt3 ITD (internal tandem duplication) promotes enhanced cell growth. In this study, we identified tyrosines 768, 955 and 969 of Flt3 as phosphorylation...

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Share to Adaptor Proteins, Signal Transducing
Share to Cell Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

Share to fms-Like Tyrosine Kinase 3

Share to Leukemia, Myeloid, Acute

Share to STAT5 Transcription Factor

Share to Tumor Cells, Cultured

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Source

Identifiers

PMID: 19438505
DOI: 10.1111/j.1365-2141.2009.07725.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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