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Article

Subtyping of microsatellite instability-high colorectal cancer

22 Jul 2019

Abstract excerpt

BACKGROUND: Patients with microsatellite instability-high (MSI-H) colorectal cancer (CRC) generally have a better prognosis than patients with microsatellite stable (MSS) CRC. However, some MSI-H CRC patients do not gain overall survival benefits from immune checkpoint-blockade treatment. In other words, heterogeneity within the subgroup of MSI-H tumors remains poorly understood. Thus, an in-depth molecular...

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PMID: 31331345
DOI: 10.1186/s12964-019-0397-4

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