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Article

Identifying pleiotropic genes for major psychiatric disorders with GWAS summary statistics using multivariate adaptive association tests.

Journal of psychiatric research - 1 Nov 2022

Wang Yuping, Yang Yongli, Jia Xiaocan, Zhao Chenyu, Yang Chaojun, Fan Jingwen, Wu Meina, Yu Mengdie, Dong Ani, Wang Nana, Lian Jiao, Shi Xuezhong

Abstract excerpt

BACKGROUND: Genome wide association studies (GWAS) have discovered a few of single nucleotide polymorphisms (SNPs) related to major psychiatric disorders. However, it is not completely clear which genes play a pleiotropic role in multiple disorders. The study aimed to identify the pleiotropic genes across five psychiatric disorders using multivariate adaptive association tests. METHODS: Summary statistics of five...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36183601
DOI: 10.1016/j.jpsychires.2022.09.038

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