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The diversity of natural killer cell functional and phenotypic states in cancer.

Cancer metastasis reviews - 24 Jan 2025

Rishabh Kumar, Matosevic Sandro

Abstract excerpt

The role of natural killer (NK) cells as immune effectors is well established, as is their utility as immunotherapeutic agents against various cancers. However, NK cells' anti-cancer roles are suppressed in cancer patients by various immunomodulatory mechanisms which alter these cells' identity, function, and potential for immunosurveillance. This manifests in abnormal NK cell responses accompanied by changes in...

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PMID: 39853430
DOI: 10.1007/s10555-025-10242-w

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