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Article

Pan-cancer analyses reveal regulation and clinical outcome association of the shelterin complex in cancer

31 Dec 2020

Abstract excerpt

Shelterin, a protective complex at telomeres, plays essential roles in cancer. In addition to maintain telomere integrity, shelterin functions in various survival pathways. However, the detailed mechanisms of shelterin regulation in cancer remain elusive. Here, we perform a comprehensive analysis of shelterin in 9125 tumor samples across 33 cancer types using multi-omic data from The Cancer Genome Atlas, and...

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Share to Epigenetics and DNA Methylation
Share to Mitochondrial Function and Pathology
Share to Telomeres, Telomerase, and Senescence

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PMID: 33497432
DOI: 10.1093/bib/bbaa441

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