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Article

Midecamycin Is Inactivated by Several Different Sugar Moieties at Its Inactivation Site.

International journal of molecular sciences - 23 Nov 2021

Lin Ru, Hong Li-Li, Jiang Zhong-Ke, Li Ke-Meng, He Wei-Qing, Kong Jian-Qiang

Abstract excerpt

Glycosylation inactivation is one of the important macrolide resistance mechanisms. The accumulated evidences attributed glycosylation inactivation to a glucosylation modification at the inactivation sites of macrolides. Whether other glycosylation modifications lead to macrolides inactivation is unclear. Herein, we demonstrated that varied glycosylation modifications could cause inactivation of midecamycin, a...

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Identifiers

PMID: 34884439
DOI: 10.3390/ijms222312636
PMCID: PMC8657839

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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