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Article

The gene cluster for the biosynthesis of the glycopeptide antibiotic A40926 by nonomuraea species.

Chemistry & biology - 1 Jun 2003

Sosio Margherita, Stinchi Sofia, Beltrametti Fabrizio, Lazzarini Ameriga, Donadio Stefano

Abstract excerpt

The glycopeptide A40926 is the precursor of dalbavancin, a second-generation glycopeptide currently under clinical development. The dbv gene cluster, devoted to A40926 biosynthesis, was isolated and characterized from the actinomycete Nonomuraea species ATCC39727. From sequence analysis, 37 open reading frames (ORFs) participate in A40926 biosynthesis, regulation, resistance, and export. Of these, 27 ORFs find a...

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Identifiers

PMID: 12837387
DOI: 10.1016/s1074-5521(03)00120-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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