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Article

Three enzymes involved in the N-methylation and incorporation of the pradimicin sugar moieties.

Bioorganic & medicinal chemistry letters - 15 Mar 2015

Napan Kandy L, Zhang Shuwei, Anderson Thomas, Takemoto Jon Y, Zhan Jixun

Abstract excerpt

Pradimicins are antifungal and antiviral natural products from Actinomadura hibisca P157-2. The sugar moieties play a critical role in the biological activities of these compounds. There are two glycosyltransferase genes in the pradimicin biosynthetic gene cluster, pdmS and pdmQ, which are putatively responsible for the introduction of the sugar moieties during pradimicin biosynthesis. In this study, we disrupted...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 25677666
DOI: 10.1016/j.bmcl.2015.01.043
PMCID: PMC4348331

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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