MAPK Signaling and Angiopoietin-2 Contribute to Endothelial Permeability in Capillary Malformations

Abstract excerpt

<h4>ABSTRACT</h4> Capillary malformations (CM) are slow-flow vascular abnormalities present at birth and predominantly manifest as cutaneous lesions. In the rare neurocutaneous disorder known as Sturge Weber Syndrome (SWS), individuals exhibit CM not only on the skin but also within the leptomeninges of the brain and the choroid of the eye. >90% of CM are caused by a somatic R183Q mutation in GNAQ, the gene enco...

Topics

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• Angiopoietin-2
• Capillaries
• Endothelial Progenitor Cells
• GTP-Binding Protein alpha Subunits, Gq-G11
• Human Umbilical Vein Endothelial Cells
• Neovascularization, Pathologic
• Phospholipase C beta
• Protein Kinase C

Identifiers and source

Literature Corpus work

9b03b5c3-18e3-5ed9-99c6-4d2f39fa63fb

DOI

10.1101/2025.03.31.646063