Article
RNA-based FLT3-ITD allelic ratio is associated with outcome and ex vivo response to FLT3 inhibitors in pediatric AML.
Blood - 31 May 2018
Cucchi David G J, Denys Barbara, Kaspers Gertjan J L, Janssen Jeroen J W M, Ossenkoppele Gert J, de Haas Valérie, Zwaan C Michel, van den Heuvel-Eibrink Marry M, Philippé Jan, Csikós Tamás, Kwidama Zinia, de Moerloose Barbara, de Bont Eveline S J M, Lissenberg-Witte Birgit I, Zweegman Sonja, Verwer Femke, Vandepoele Karl, Schuurhuis Gerrit Jan, Sonneveld Edwin, Cloos Jacqueline
Abstract excerpt
Controversy exists whether internal tandem duplication of FMS-like tyrosine kinase 3 (FLT3-internal tandem duplication [ITD]) allelic ratio (AR) and/or length of the ITD should be taken into account for risk stratification of pediatric acute myeloid leukemia (AML) and whether it should be measured on RNA or DNA. Moreover, the ITD status may be of relevance for selecting patients eligible for FLT3 inhibitors....
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