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Article

A common deletion in the APOBEC3 genes and breast cancer risk.

Journal of the National Cancer Institute - 17 Apr 2013

Long Jirong, Delahanty Ryan J, Li Guoliang, Gao Yu-Tang, Lu Wei, Cai Qiuyin, Xiang Yong-Bing, Li Chun, Ji Bu-Tian, Zheng Ying, Ali Simak, Shu Xiao-Ou, Zheng Wei

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWASs) have identified multiple genetic susceptibility loci for breast cancer. However, these loci explain only a small fraction of the heritability. Very few studies have evaluated copy number variation (CNV), another important source of human genetic variation, in relation to breast cancer risk. METHODS: We conducted a CNV GWAS in 2623 breast cancer patients and 1946...

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Share to APOBEC Deaminases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23411593
DOI: 10.1093/jnci/djt018
PMCID: PMC3627644

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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A common deletion in the APOBEC3 genes and breast cancer risk.PMID 23411593Read ↗

APOBEC3 deletion polymorphism is associated with breast cancer risk among women of European ancestry.Semantic proximity Read ↗

Rare Copy Number Variants (CNVs) and Breast Cancer RiskSemantic proximity Read ↗

Rare copy number variants (CNVs) and breast cancer riskSemantic proximity Read ↗

Increased genomic burden of germline copy number variants is associated with early onset breast cancer: Australian breast cancer family registry.Semantic proximity Read ↗

Germline copy number variations are associated with breast cancer risk and prognosis.Semantic proximity Read ↗

APOBEC3 deletion increases the risk of breast cancer: a meta-analysis.Semantic proximity Read ↗

APOBEC3 deletion polymorphism is associated with epithelial ovarian cancer risk among Chinese women.Semantic proximity Read ↗

Origins and functional impact of copy number variation in the human genome.Semantic proximity Read ↗

The 30 kb deletion in the APOBEC3 cluster decreases APOBEC3A and APOBEC3B expression and creates a transcriptionally active hybrid gene but does not associate with breast cancer in the European populationSemantic proximity Read ↗

Rare copy number variants observed in hereditary breast cancer cases disrupt genes in estrogen signaling and TP53 tumor suppression network.Semantic proximity Read ↗

SgD-CNV, a database for common and rare copy number variants in three Asian populations.Semantic proximity Read ↗

Copy number variants as modifiers of breast cancer risk for BRCA1/BRCA2 pathogenic variant carriers.Semantic proximity Read ↗

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