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Article

Small-scale variants and large deletions in BRCA1/2 genes in Slovak high-grade serous ovarian cancer.

Pathology, research and practice - 1 Jun 2023

Janíková Katarína, Váňová Barbora, Grendár Marián, Samec Marek, Loderer Dušan, Kašubová Ivana, Škereňová Mária, Farkašová Anna, Scheerová Karla, Slávik Pavol, Lasabová Zora, Danková Zuzana, Strnádel Ján, Halašová Erika, Plank Lukáš

Abstract excerpt

The role of PARP inhibitors is to prevent the polymerase from repairing the single-strand break that occurred due to tumor growth and thus induce cell apoptosis when the homologous recombination deficiency (HRD) system is disabled. The eliminated system can be monitored especially in patients with serous ovarian epithelial tumors. Current studies still show the highest progression-free survival (PFS) in the...

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PMID: 37121054
DOI: 10.1016/j.prp.2023.154475

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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