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OXA-23 β-Lactamase Overexpression in Acinetobacter baumannii Drives Physiological Changes Resulting in New Genetic Vulnerabilities.

mBio - 21 Dec 2021

Colquhoun Jennifer M, Farokhyfar Marjan, Hutcheson Anna R, Anderson Alexander, Bethel Christopher R, Bonomo Robert A, Clarke Anthony J, Rather Philip N

Abstract excerpt

β-Lactamase expression is the major mechanism of resistance to penicillins, cephalosporins, and carbapenems in the multidrug-resistant (MDR) bacterium Acinetobacter baumannii. In fact, stable high-level expression of at least one β-lactamase has been rapidly increasing and reported to occur in up to 98.5% of modern A. baumannii isolates recovered in the clinic. Moreover, the OXA-51 β-lactamase is universally...

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Identifiers

PMID: 34872351
DOI: 10.1128/mBio.03137-21
PMCID: PMC8649759

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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