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Article

A global regulatory system links virulence and antibiotic resistance to envelope homeostasis in Acinetobacter baumannii.

PLoS pathogens - 1 May 2018

Geisinger Edward, Mortman Nadav J, Vargas-Cuebas Germán, Tai Albert K, Isberg Ralph R

Abstract excerpt

The nosocomial pathogen Acinetobacter baumannii is a significant threat due to its ability to cause infections refractory to a broad range of antibiotic treatments. We show here that a highly conserved sensory-transduction system, BfmRS, mediates the coordinate development of both enhanced virulence and resistance in this microorganism. Hyperactive alleles of BfmRS conferred increased protection from serum...

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Identifiers

PMID: 29795704
DOI: 10.1371/journal.ppat.1007030
PMCID: PMC5967708

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