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Article

Antibiotic susceptibility signatures identify potential antimicrobial targets in the Acinetobacter baumannii cell envelope.

Nature communications - 9 Sept 2020

Geisinger Edward, Mortman Nadav J, Dai Yunfei, Cokol Murat, Syal Sapna, Farinha Andrew, Fisher Delaney G, Tang Amy Y, Lazinski David W, Wood Stephen, Anthony Jon, van Opijnen Tim, Isberg Ralph R

Abstract excerpt

A unique, protective cell envelope contributes to the broad drug resistance of the nosocomial pathogen Acinetobacter baumannii. Here we use transposon insertion sequencing to identify A. baumannii mutants displaying altered susceptibility to a panel of diverse antibiotics. By examining mutants with antibiotic susceptibility profiles that parallel mutations in characterized genes, we infer the function of multiple...

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Identifiers

PMID: 32908144
DOI: 10.1038/s41467-020-18301-2
PMCID: PMC7481262

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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