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Genome-wide CRISPR/Cas9 screen identifies host factors for Newcastle disease virus replication

10 Jun 2025

Abstract excerpt

Viruses rely strictly on host factors to determine their susceptibility. Newcastle disease virus (NDV), an avian pathogen, can infect a wide range of avian, mammalian and human cell lines. However, NDV can only infect certain mammals and humans, and it does not cause disease in mammals or mice. A comprehensive identification of NDV-susceptible host genes that promote NDV infection is lacking. Here, we performed a...

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PMID: 40541099
DOI: 10.1016/j.psj.2025.105421

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