Article
15-Lipoxygenase worsens renal fibrosis, inflammation, and metabolism in a murine model of ureteral obstruction.
American journal of physiology. Renal physiology - 1 Jan 2022
Montford John R, Bauer Colin, Rahkola Jeremy, Reisz Julie A, Floyd Deanna, Hopp Katharina, Soranno Danielle E, Klawitter Jelena, Weiser-Evans Mary C M, Nemenoff Raphael, Faubel Sarah, Furgeson Seth B
Abstract excerpt
15-Lipoxygenase (15-LO) is a nonheme iron-containing dioxygenase that has both pro- and anti-inflammatory roles in many tissues and disease states. 15-LO is thought to influence macrophage phenotype, and silencing 15-LO reduces fibrosis after acute inflammatory triggers. The goal of the present study was to determine whether altering 15-LO expression influences inflammation and fibrogenesis in a murine model of...
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