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Elevation of ISG15 promotes diabetic kidney disease by modulating renal tubular epithelial cell pyroptosis

1 Jun 2025

Abstract excerpt

BACKGROUND: Fibrosis and inflammation in the renal tubular epithelial cells (TECs) are key contributors to the pathology of diabetic kidney disease (DKD). Nevertheless, the precise triggers of these processes remain unclear. This study aimed to explore the role of interferon-stimulated gene 15 (ISG15) in the injury of TECs induced by high glucose (HG) conditions and its implications for the development of DKD....

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PMID: 40462493
DOI: 10.1002/ctm2.70337

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