Tissue transglutaminase exacerbates renal fibrosis via alternative activation of monocyte-derived macrophages

Abstract excerpt

<title>Abstract</title> <p>Macrophages are important components in modulating homeostatic and inflammatory responses and are generally categorized into two broad but distinct subsets: classical activated (M1) and alternatively activated (M2) depending on the microenvironment. Fibrosis is a chronic inflammatory disease exacerbated by M2 macrophages, although the detailed mechanism by which M2 macrophage polarizati...

Topics

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• Cell- and Tissue-Based Therapy
• Cell Proliferation
• Kidney Diseases
• Macrophages
• Mice
• Models, Animal
• Nephritis
• Phenotype

Identifiers and source

Literature Corpus work

9e7f2191-c8db-53b9-b3fb-d429c1e995b3

DOI

10.21203/rs.3.rs-2156542/v1