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Article

Role and Mechanism of Growth Differentiation Factor 15 in Chronic Kidney Disease

1 May 2024

Abstract excerpt

GDF-15 is an essential member of the transforming growth factor-beta superfamily. Its functions mainly involve in tissue injury, inflammation, fibrosis, regulation of appetite and weight, development of tumor, and cardiovascular disease. GDF-15 is involved in various signaling pathways, such as MAPK pathway, PI3K/AKT pathway, STAT3 pathway, RET pathway, and SMAD pathway. In addition, several factors such as p53,...

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PMID: 38741613
DOI: 10.2147/jir.s451398

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