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Article

The 12/15-lipoxygenase pathway counteracts fibroblast activation and experimental fibrosis.

Annals of the rheumatic diseases - 1 Jun 2012

Krönke Gerhard, Reich Nicole, Scholtysek Carina, Akhmetshina Alfiya, Uderhardt Stefan, Zerr Pawel, Palumbo Katrin, Lang Veronika, Dees Clara, Distler Oliver, Schett Georg, Distler Jörg H W

Abstract excerpt

BACKGROUND: Idiopathic and inflammation-dependent fibrotic diseases such systemic sclerosis (SSc) impose a major burden on modern societies. Understanding endogenous mechanisms, which counteract fibrosis, may yield new therapeutic approaches. Lipoxins are highly potent lipid mediators, which have recently been found to be decreased in SSc. OBJECTIVES: To determine the potential role of 12/15-lipoxygenase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22267335
DOI: 10.1136/annrheumdis-2011-200745

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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