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Identification of IgG1 and IgG3 Allotypes by PCR and Sanger Sequencing.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2024

Aurelia L Carissa, Purcell Ruth A, Chung Amy W

Abstract excerpt

The immunoglobulin heavy constant gamma (IGHG) gene cluster encoding immunoglobulin G (IgG) subclasses is highly polymorphic, resulting in amino acid variation along the antibody constant heavy chain referred to as allotypes. IGHG1 and IGHG3 are the two most polymorphic IgG subclasses in humans, with 4 classical IgG1 allotypes and 13 allotypes described for IgG3, though recent studies suggest greater allelic...

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PMID: 39017895
DOI: 10.1007/978-1-0716-3950-4_15

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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