High performance of integrase genotyping on diverse HIV-1 clades circulating in Cameroon: toward a successful transition to dolutegravir-based regimens in low and middle-income countries.

doi:10.1016/j.diagmicrobio.2021.115574

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Article

High performance of integrase genotyping on diverse HIV-1 clades circulating in Cameroon: toward a successful transition to dolutegravir-based regimens in low and middle-income countries.

Diagnostic microbiology and infectious disease - 1 Feb 2022

Fokam Joseph, Ngoufack Jagni Semengue Ezechiel, Armenia Daniele, Takou Désiré, Dambaya Béatrice, Teto Georges, Chenwi Collins Ambe, Nka Alex Durand, Beloumou Grâce Angong, Ndjeyep Sandrine Claire Djupsa, Tchouaket Michel Carlos Tommo, Fainguem Nadine, Sosso Samuel Martin, Colizzi Vittorio, Perno Carlo-Federico, Ndjolo Alexis, Ceccherini-Silberstein Francesca, Santoro Maria Mercedes

Abstract excerpt

A successful transition to dolutegravir-based regimens in low and middle-income countries (LMICs) requires an integrase genotyping assay effective on diverse HIV-1 clades. We herein developed and validated an in-house integrase genotyping protocol on plasma samples from 195 HIV-infected patients in Cameroon. Median [IQR] viremia was 23,574 (518-109,235) copies/mL; 128/195 participants had ≥1000copies/mL (i.e.,...

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PMID: 34864527
DOI: 10.1016/j.diagmicrobio.2021.115574

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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