Article
Pre-Treatment HIV Drug Resistance and Genetic Diversity in Cameroon: Implications for First-Line Regimens.
Viruses - 28 Jun 2023
Fokam Joseph, Chenwi Collins Ambe, Tala Valère, Takou Désiré, Santoro Maria Mercedes, Teto George, Dambaya Beatrice, Anubodem Felix, Semengue Ezechiel Ngoufack Jagni, Beloumou Grace, Djupsa Sandrine, Assomo Edgar, Fokunang Charles, Alteri Claudia, Billong Serge, Bouba Nounouce Pamen, Ajeh Rogers, Colizzi Vittorio, Mbanya Dora, Ceccherini-Silberstein Francesca, Perno Carlo-Federico, Ndjolo Alexis
Abstract excerpt
The efficacy of first-line antiretroviral therapy (ART) may be hampered by the presence of HIV drug resistance (HIVDR). We described HIV-1 pre-treatment drug resistance (PDR) patterns, effect of viral clades on PDR, and programmatic implications on first-line regimens in Cameroon. A sentinel surveillance of PDR was conducted from 2014 to 2019. Sequencing of HIV-1 protease and reverse transcriptase was performed,...
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