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Article

Impact of FLT3 internal tandem duplication and NPM1 mutations in acute myeloid leukemia treated with allogeneic hematopoietic cell transplantation.

Cytotherapy - 1 Apr 2022

Khanolkar Rutvij A, Faridi Rehan M, Kinzel Megan, Jamani Kareem, Savoie Mary L, Shafey Mona, Khan Faisal M, Storek Jan

Abstract excerpt

BACKGROUND AIMS: The internal tandem duplication of FLT3 (FLT3ITD) and NPM1 mutations (NPM1mut) are well-established prognostic factors in cytogenetically intermediate-risk acute myeloid leukemia (AML) when treated with chemotherapy alone. However, their prognostic value in the setting of allogeneic hematopoietic cell transplantation (HCT) is controversial. METHODS: FLT3 and NPM1 mutational status was determined...

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Identifiers

PMID: 34863627
DOI: 10.1016/j.jcyt.2021.10.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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