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Article

Adverse impact of a high allelic burden FLT3-ITD mutation on allogeneic hematopoietic stem cell transplantation in patients with cytogenetically normal AML.

International journal of hematology - 1 Nov 2022

Wan Li, Ding Shuqi, Xu Mimi, Lv Kangkang, Du Yuanyuan, Wu Depei, Xu Mingzhu, Liu Yuejun

Abstract excerpt

Risks associated with the FLT3-ITD mutation in patients receiving chemotherapy alone for cytogenetic normal acute myeloid leukemia (CN-AML) depend on the allelic ratio (AR) and concomitant NPM1 mutation. Nevertheless, their prognostic ability after allogeneic hematopoietic cell transplantation (allo-HCT) remains undetermined. Moreover, previous studies have revealed that haploidentical transplantation improves...

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PMID: 35857193
DOI: 10.1007/s12185-022-03423-8

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