Interaction of MIF Family Proteins in Myocardial Ischemia/Reperfusion Damage and Their Influence on Clinical Outcome of Cardiac Surgery Patients.

doi:10.1089/ars.2014.6243

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Article

Interaction of MIF Family Proteins in Myocardial Ischemia/Reperfusion Damage and Their Influence on Clinical Outcome of Cardiac Surgery Patients.

Antioxidants & redox signaling - 10 Oct 2015

Stoppe Christian, Rex Steffen, Goetzenich Andreas, Kraemer Sandra, Emontzpohl Christoph, Soppert Josefin, Averdunk Luisa, Sun Yu, Rossaint Rolf, Lue Hongqi, Huang Caleb, Song Yan, Pantouris Georgios, Lolis Elias, Leng Lin, Schulte Wibke, Bucala Richard, Weber Christian, Bernhagen Jürgen

Abstract excerpt

AIMS: Cardiac surgery involves myocardial ischemia/reperfusion (I/R) with potentially deleterious consequences. Macrophage migration inhibitory factor (MIF) is a stress-regulating chemokine-like cytokine that protects against I/R damage, but functional links with its homolog, d-dopachrome tautomerase (MIF-2), and the circulating soluble receptor CD74 (sCD74) are unknown. In this study, we investigate the role of...

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PMID: 26234719
DOI: 10.1089/ars.2014.6243
PMCID: PMC4615780

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