Article
Macrophage migration inhibitory factor in acute lung injury: expression, biomarker, and associations.
Translational research : the journal of laboratory and clinical medicine - 1 Jul 2007
Gao Li, Flores Carlos, Fan-Ma Shwu, Miller Edmund J, Moitra Jaideep, Moreno Liliana, Wadgaonkar Raj, Simon Brett, Brower Roy, Sevransky Jonathan, Tuder Rubin M, Maloney James P, Moss Marc, Shanholtz Carl, Yates C Ryan, Meduri Gianfranco Umberto, Ye Shui Q, Barnes Kathleen C, Garcia Joe G N
Abstract excerpt
The macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine central to the response to endotoxemia, is a putative biomarker in acute lung injury (ALI). To explore MIF as a molecular target and candidate gene in ALI, the MIF gene and protein expression were examined in murine and canine models of ALI (high tidal volume mechanical ventilation, endotoxin exposure) and in patients with either sepsis...
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