Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural determinants of MIF functions in CXCR2-mediated inflammatory and atherogenic leukocyte recruitment.

Proceedings of the National Academy of Sciences of the United States of America - 21 Oct 2008

Weber Christian, Kraemer Sandra, Drechsler Maik, Lue Hongqi, Koenen Rory R, Kapurniotu Aphrodite, Zernecke Alma, Bernhagen Jürgen

Abstract excerpt

We have recently identified the archaic cytokine macrophage migration inhibitory factor (MIF) as a non-canonical ligand of the CXC chemokine receptors CXCR2 and CXCR4 in inflammatory and atherogenic cell recruitment. Because its affinity for CXCR2 was particularly high, we hypothesized that MIF may feature structural motives shared by canonical CXCR2 ligands, namely the conserved N-terminal Glu-Leu-Arg (ELR)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atherosclerosis
Share to Cell Movement

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inflammation

Share to Leukocytes

Share to Macrophage Migration-Inhibitory Factors

Share to Mice, Knockout

Share to Protein Structure, Quaternary

Share to Receptors, Interleukin-8B

Source

Open in PubMed Open full text

Identifiers

PMID: 18852457
DOI: 10.1073/pnas.0804017105
PMCID: PMC2566990

Genes

MIF
CXCR2
CXCR4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural determinants of MIF functions in CXCR2-mediated inflammatory and atherogenic leukocyte recruitment.PMID 18852457Read ↗

The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular diseaseSemantic proximity Read ↗

MIF-2/D-DT is an atypical atherogenic chemokine that promotes advanced atherosclerosis and hepatic lipogenesisSemantic proximity Read ↗

Role and implications of the CXCL12/CXCR4/CXCR7 axis in atherosclerosis: still a debateSemantic proximity Read ↗

Heterocomplexes between the Atypical Chemokine MIF and the CXC-Motif Chemokine CXCL4L1 Regulate Inflammation and Thrombus FormationSemantic proximity Read ↗

Heterocomplexes between the Atypical Chemokine MIF and the CXC-Motif Chemokine CXCL4L1 Regulate Inflammation and Thrombus FormationSemantic proximity Read ↗

Diversity and Inter-Connections in the CXCR4 Chemokine Receptor/Ligand Family: Molecular PerspectivesSemantic proximity Read ↗

Macrophage migration inhibitory factor (MIF): a promising biomarker.Semantic proximity Read ↗

Monocyte chemoattractant protein-1 (MCP-1): an overview.Semantic proximity Read ↗

Structural and functional characterization of human CXCR4 as a chemokine receptor and HIV-1 co-receptor by mutagenesis and molecular modeling studies.Semantic proximity Read ↗

A model of GAG/MIP-2/CXCR2 interfaces and its functional effects.Semantic proximity Read ↗

Characterization of the chemokine CXCL11-heparin interaction suggests two different affinities for glycosaminoglycans.Semantic proximity Read ↗

Structural basis for chemokine recognition by a G protein-coupled receptor and implications for receptor activation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.