Article
Macrophage migration inhibitory factor enzymatic activity, lung inflammation, and cystic fibrosis.
American journal of respiratory and critical care medicine - 15 Jul 2012
Adamali Huzaifa, Armstrong Michelle E, McLaughlin Anne Marie, Cooke Gordon, McKone Edward, Costello Christine M, Gallagher Charles G, Leng Lin, Baugh John A, Fingerle-Rowson Günter, Bucala Richard J, McLoughlin Paul, Donnelly Seamas C
Abstract excerpt
RATIONALE: Macrophage migration inhibitory factor (MIF) is a proinflammatory mediator with unique tautomerase enzymatic activity; the precise function has not been clearly defined. We previously demonstrated that individual patients with cystic fibrosis (CF) who are genetically predisposed to be high MIF producers develop accelerated end-organ injury. OBJECTIVES: To characterize the effects of the MIF-CATT...
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