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Article

MIF-2/D-DT enhances proximal tubular cell regeneration through SLPI- and ATF4-dependent mechanisms.

American journal of physiology. Renal physiology - 1 Sept 2017

Ochi Akinobu, Chen Dong, Schulte Wibke, Leng Lin, Moeckel Nickolas, Piecychna Marta, Averdunk Luisa, Stoppe Christian, Bucala Richard, Moeckel Gilbert

Abstract excerpt

Macrophage migration inhibitory factor (MIF) is a cytokine with pleiotropic actions that is produced by several organs and cell types. Depending on the target cell and the inflammatory context, MIF can engage its two component receptor complex CD74 and CD44 and the chemokine receptors CXCR2/4. MIF is constitutively expressed in renal proximal tubular cells, stored in intracellular preformed pools, and released at...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 28539339
DOI: 10.1152/ajprenal.00683.2016
PMCID: PMC6148305

Genes

MIF
SLPI
ATF4
CXCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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