Article
Evolution under Spatially Heterogeneous Selection in Solid Tumors.
Molecular biology and evolution - 7 Jan 2022
Li Guanghao, Yang Zuyu, Wu Dafei, Liu Sixue, Li Xuening, Li Tao, Li Yawei, Liang Liji, Zou Weilong, Wu Chung-I, Wang Hurng-Yi, Lu Xuemei
Abstract excerpt
Spatial genetic and phenotypic diversity within solid tumors has been well documented. Nevertheless, how this heterogeneity affects temporal dynamics of tumorigenesis has not been rigorously examined because solid tumors do not evolve as the standard population genetic model due to the spatial constraint. We therefore, propose a neutral spatial (NS) model whereby the mutation accumulation increases toward the...
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