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Article

Effect of CYP2C19 polymorphisms on serum valproic level acid in Chinese Han patients with schizophrenia.

Scientific reports - 30 Nov 2021

Wang S, Li J, Song M, Yan P, Ju X, Liu J, Wang C, Shi J

Abstract excerpt

Valproic acid is an anticonvulsant, which is also widely used for treating psychiatric disorders. Some clinical trials have demonstrated benefits of valproic acid augmentation therapy in schizophrenia. Interindividual variability in valproic acid dose and serum concentration may reflect functional consequences of genetic polymorphisms in genes encoding drug-metabolizing enzymes. The aim of this study was to...

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Identifiers

PMID: 34848811
DOI: 10.1038/s41598-021-02628-x
PMCID: PMC8632882

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