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Article

Stochastic Epigenetic Mutations Influence Parkinson's Disease Risk, Progression, and Mortality.

Journal of Parkinson's disease - 1 Jan 2022

Chen Gary K, Yan Qi, Paul Kimberly C, Kusters Cynthia D J, Folle Aline Duarte, Furlong Melissa, Keener Adrienne, Bronstein Jeff, Horvath Steve, Ritz Beate

Abstract excerpt

BACKGROUND: Stochastic epigenetic mutations (SEM) reflect a deviation from normal site-specific methylation patterns. Epigenetic mutation load (EML) captures the accumulation of SEMs across an individual's genome and may reflect dysfunction of the epigenetic maintenance system in response to epigenetic challenges. OBJECTIVE: We investigate whether EML is associated with PD risk and time to events (i.e., death and...

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Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenetics and DNA Methylation

Share to Genetic Associations and Epidemiology

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Share to Parkinson's Disease Mechanisms and Treatments

Source

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Identifiers

PMID: 34842194
DOI: 10.3233/JPD-212834
PMCID: PMC9076404

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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