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Article

Regulation of SIRT1 by Oxidative Stress-Responsive miRNAs and a Systematic Approach to Identify Its Role in the Endothelium

11 Mar 2013

Abstract excerpt

SIGNIFICANCE: Oxidative stress is a common denominator of various risk factors contributing to endothelial dysfunction and vascular diseases. Accumulated evidence suggests that sirtuin 1 (SIRT1) expression and/or activity is impaired by supraphysiological levels of oxidative stress, which in turn disrupts endothelial homeostasis. RECENT ADVANCES: Several microRNAs (miRNAs) are induced by oxidative stress and...

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PMID: 23477488
DOI: 10.1089/ars.2012.4803

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