Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype.

Cardiovascular research - 1 Feb 2010

Gracia-Sancho Jorge, Villarreal Guadalupe, Zhang Yuzhi, García-Cardeña Guillermo

Abstract excerpt

AIMS: Resveratrol activates Sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide-dependent deacetylase which modulates metabolic homeostasis and improves several pathophysiological features present in diseases of ageing. In particular, it has been shown that SIRT1 activation improves endothelial dysfunction and suppresses vascular inflammation, two central pathophysiological processes involved in the initiation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenylate Kinase
Share to Kruppel-Like Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MADS Domain Proteins

Share to MEF2 Transcription Factors

Share to Myogenic Regulatory Factors

Share to Resveratrol

Share to Sirtuin 1

Share to Stilbenes

Source

Open in PubMed Open full text

Identifiers

PMID: 19815564
DOI: 10.1093/cvr/cvp337
PMCID: PMC2802207

Genes

SIRT1
KLF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype.PMID 19815564Read ↗

Emerging roles of SIRT1 in vascular endothelial homeostasisSemantic proximity Read ↗

Endothelial SIRT1 as a Target for the Prevention of Arterial Aging: Promises and ChallengesSemantic proximity Read ↗

The Multifaceted Role of Endothelial Sirt1 in Vascular Aging: An UpdateSemantic proximity Read ↗

The enigmatic role of SIRT2 in the cardiovascular system: Deciphering its protective and detrimental actions to unlock new avenues for therapeutic interventionSemantic proximity Read ↗

Sirtuin 1 in Endothelial Dysfunction and Cardiovascular AgingSemantic proximity Read ↗

SIRT6 protects against endothelial dysfunction and atherosclerosis in miceSemantic proximity Read ↗

SIRT6 in Vascular Diseases, from Bench to BedsideSemantic proximity Read ↗

Sirtuins in vascular diseases: Emerging roles and therapeutic potentialSemantic proximity Read ↗

Regulation of SIRT1 by Oxidative Stress-Responsive miRNAs and a Systematic Approach to Identify Its Role in the EndotheliumSemantic proximity Read ↗

Sirtuin 2 deficiency aggravates ageing-induced vascular remodelling in humans and miceSemantic proximity Read ↗

SIRT1/eNOS Axis as a Potential Target against Vascular Senescence, Dysfunction and AtherosclerosisSemantic proximity Read ↗

Roles of Sirtuins in Cardiovascular Diseases: Mechanisms and TherapeuticsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.