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Article

SIRT1 and SIRT6 Signaling Pathways in Cardiovascular Disease Protection

29 Jun 2017

Abstract excerpt

Significance: Oxidative stress represents the common hallmark of pathological conditions associated with cardiovascular disease (CVD), including atherosclerosis, heart failure, hypertension, aging, diabetes, and other vascular system-related diseases. The sirtuin (SIRT) family, comprising seven proteins (SIRT1–SIRT7) sharing a highly conserved nicotinamide adenine dinucleotide (NAD + )-binding catalytic domain,...

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PMID: 28661724
DOI: 10.1089/ars.2017.7178

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