Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

E239K mutation abolishes the suppressive effects of lysine-specific demethylase 1 on migration and invasion of MCF7 cells.

Cancer science - 1 Feb 2022

Zhang Yu, Wu Tong, Zhao Bo, Liu Ziyu, Qian Rui, Zhang Jing, Shi Yueru, Wan Youzhong, Li Zhe, Hu Xin

Abstract excerpt

Lysine-specific demethylase 1 (LSD1) is an important histone demethylase that mediates epithelial to mesenchymal transition (EMT). The E239K mutation of LSD1 was identified in a luminal breast cancer patient from the COSMIC Breast Cancer dataset. To investigate the functional effects of the E239K mutation of LSD1, a stable LSD1 knockdown MCF7 cell line was generated. Rescue with WT LSD1, but not E239K mutated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion
Share to Cell Movement

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial-Mesenchymal Transition

Share to Estrogen Receptor alpha

Share to GATA3 Transcription Factor

Share to Gene Expression Regulation, Neoplastic

Share to Histone Demethylases

Share to MCF-7 Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 34839571
DOI: 10.1111/cas.15220
PMCID: PMC8819338

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

E239K mutation abolishes the suppressive effects of lysine-specific demethylase 1 on migration and invasion of MCF7 cells.PMID 34839571Read ↗

The R251Q mutation of LSD1 promotes invasion and migration of luminal breast cancer cells.Semantic proximity Read ↗

Lysine-Specific Demethylase 1 (LSD1) Modulates Hypoxia and Antitumor Immunity Pathways in Triple Negative Breast CancerSemantic proximity Read ↗

Histone demethylase LSD1 controls the phenotypic plasticity of cancer cells.Semantic proximity Read ↗

Increased Protein and Transcript Expression Levels of Lysine-Specific Demethylase 1 (LSD1) Signify Worse Prognosis in Triple-Negative Breast CancerSemantic proximity Read ↗

Lysine-Specific Demethylase 1 (LSD1)-Mediated Epigenetic Modification of Immunogenicity and Immunomodulatory Effects in Breast CancersSemantic proximity Read ↗

Phosphorylation of LSD1 at Ser112 is crucial for its function in induction of EMT and metastasis in breast cancer.Semantic proximity Read ↗

Nm23-H1 Suppresses Tumor Cell Motility by Down-regulating the Lysophosphatidic Acid Receptor <i>EDG2</i>Semantic proximity Read ↗

Lysine demethylase KDM3A regulates breast cancer cell invasion and apoptosis by targeting histone and the non-histone protein p53.Semantic proximity Read ↗

MOF Acetylates the Histone Demethylase LSD1 to Suppress Epithelial-to-Mesenchymal Transition.Semantic proximity Read ↗

A Novel Therapeutic Strategy Targeting the Mesenchymal Phenotype of Malignant Pleural Mesothelioma by Suppressing LSD1.Semantic proximity Read ↗

LSD1 modulates the non-canonical integrin β3 signaling pathway in non-small cell lung carcinoma cells.Semantic proximity Read ↗

LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.