Article
A Novel Therapeutic Strategy Targeting the Mesenchymal Phenotype of Malignant Pleural Mesothelioma by Suppressing LSD1.
Molecular cancer research : MCR - 1 Jan 2022
Wirawan Aditya, Tajima Ken, Takahashi Fumiyuki, Mitsuishi Yoichiro, Winardi Wira, Hidayat Moulid, Hayakawa Daisuke, Matsumoto Naohisa, Izumi Kenta, Asao Tetsuhiko, Ko Ryo, Shimada Naoko, Takamochi Kazuya, Suzuki Kenji, Abe Masaaki, Hino Okio, Sekido Yoshitaka, Takahashi Kazuhisa
Abstract excerpt
Malignant pleural mesothelioma (MPM) is a highly aggressive tumor that has a low overall survival; however, no significant treatment advances have been made in the past 15 years. Large-scale molecular studies have identified a poor prognostic subset of MPM linked to the epithelial-mesenchymal transition (EMT) that may contribute toward resistance to chemotherapy, suggesting that EMT could be targeted to treat...
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