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Article

MOF Acetylates the Histone Demethylase LSD1 to Suppress Epithelial-to-Mesenchymal Transition.

Cell reports - 21 Jun 2016

Luo Huacheng, Shenoy Anitha K, Li Xuehui, Jin Yue, Jin Lihua, Cai Qingsong, Tang Ming, Liu Yang, Chen Hao, Reisman David, Wu Lizi, Seto Edward, Qiu Yi, Dou Yali, Casero Robert A, Lu Jianrong

Abstract excerpt

The histone demethylase LSD1 facilitates epithelial-to-mesenchymal transition (EMT) and tumor progression by repressing epithelial marker expression. However, little is known about how its function may be modulated. Here, we report that LSD1 is acetylated in epithelial but not mesenchymal cells. Acetylation of LSD1 reduces its association with nucleosomes, thus increasing histone H3K4 methylation at its target...

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Identifiers

PMID: 27292636
DOI: 10.1016/j.celrep.2016.05.050

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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