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Article

LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer.

Scientific reports - 8 Jan 2018

Boulding T, McCuaig R D, Tan A, Hardy K, Wu F, Dunn J, Kalimutho M, Sutton C R, Forwood J K, Bert A G, Goodall G J, Malik L, Yip D, Dahlstrom J E, Zafar A, Khanna K K, Rao S

Abstract excerpt

Complex regulatory networks control epithelial-to-mesenchymal transition (EMT) but the underlying epigenetic control is poorly understood. Lysine-specific demethylase 1 (LSD1) is a key histone demethylase that alters the epigenetic landscape. Here we explored the role of LSD1 in global epigenetic regulation of EMT, cancer stem cells (CSCs), the tumour microenvironment, and therapeutic resistance in breast cancer....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29311580
DOI: 10.1038/s41598-017-17913-x
PMCID: PMC5758711

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