Article
Phosphorylation of LSD1 at Ser112 is crucial for its function in induction of EMT and metastasis in breast cancer.
Breast cancer research and treatment - 1 Oct 2016
Feng Jingxin, Xu Guiying, Liu Jiwei, Zhang Na, Li Lili, Ji Jiafei, Zhang Jianchao, Zhang Lian, Wang Guannan, Wang Xiuli, Tan Jiang, Huang Baiqu, Lu Jun, Zhang Yu
Abstract excerpt
PURPOSE: LSD1 is overexpressed in various cancers including breast cancer, but its functional roles in tumourigenesis are not fully understood. This study aims at revealing the role of LSD1 in breast cancer development. In addition, it has been reported that phosphorylation of the Serine 112 residue of LSD1 by PKCα is crucial for its function in gene regulation. We also explored whether this phosphorylation...
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