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Article

The R251Q mutation of LSD1 promotes invasion and migration of luminal breast cancer cells.

International journal of biological macromolecules - 1 Dec 2020

Zhang Yu, Wu Tong, Wang Yajing, Zhao Xinyue, Zhao Bo, Zhao Xue, Zhang Qinglin, Jin Yue, Li Zhe, Hu Xin

Abstract excerpt

LSD1 (KDM1A), a histone demethylase, plays important roles in breast cancer. The breast cancer patients with LSD1 mutation show significantly worse outcomes compared to those without LSD1 mutation. The R251Q mutation of LSD1 increases the invasion and migration of luminal breast cancer cells. Furthermore, the R251Q mutation of LSD1 alters the expression of genes that modulates the epithelial to mesenchymal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32882276
DOI: 10.1016/j.ijbiomac.2020.08.221

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