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Gynecological Cancers Caused by Deficient Mismatch Repair and Microsatellite Instability

10 Nov 2020

Abstract excerpt

Mutations in mismatch repair genes leading to mismatch repair (MMR) deficiency (dMMR) and microsatellite instability (MSI) have been implicated in multiple types of gynecologic malignancies. Endometrial carcinoma represents the largest group, with approximately 30% of these cancers caused by dMMR/MSI. Thus, testing for dMMR is now routine for endometrial cancer. Somatic mutations leading to dMMR account for...

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Cancer Genomics and Diagnostics
Genetic factors in colorectal cancer
Multiple and Secondary Primary Cancers

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33182707
DOI: 10.3390/cancers12113319

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