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Article

Spermidine Supplementation Protects the Liver Endothelium from Liver Damage in Mice.

Nutrients - 21 Oct 2021

Campreciós Genís, Ruart Maria, Anton Aina, Suárez-Herrera Nuria, Montironi Carla, Martínez Celia, Jiménez Natalia, Lafoz Erica, García-Calderó Héctor, Vilaseca Marina, Magaz Marta, Coll Mar, Graupera Isabel, Friedman Scott L, García-Pagán Joan Carles, Hernández-Gea Virginia

Abstract excerpt

Chronic liver diseases are multifactorial and the need to develop effective therapies is high. Recent studies have shown the potential of ameliorating liver disease progression through protection of the liver endothelium. Polyamine spermidine (SPD) is a caloric restriction mimetic with autophagy-enhancing properties capable of prolonging lifespan and with a proven beneficial effect in cardiovascular disease in...

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Identifiers

PMID: 34835956
DOI: 10.3390/nu13113700
PMCID: PMC8617984

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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