Molecular targets of spermidine: implications for cancer suppression

Abstract excerpt

Spermidine is a ubiquitous, natural polyamine with geroprotective features. Supplementation of spermi-dine extends the lifespan of yeast, worms, flies, and mice, and dietary spermidine intake correlates with reduced human mortality. However, the crucial role of polyamines in cell proliferation has also implicated poly-amine metabolism in neoplastic diseases, such as cancer. While depleting intracellular polyamine...