Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Restoration of liver sinusoidal cell phenotypes by statins improves portal hypertension and histology in rats with NASH.

Scientific reports - 27 Dec 2019

Bravo Miren, Raurell Imma, Hide Diana, Fernández-Iglesias Anabel, Gil Mar, Barberá Aurora, Salcedo Maria Teresa, Augustin Salvador, Genescà Joan, Martell María

Abstract excerpt

Non-alcoholic steatohepatitis (NASH) is a common chronic liver disorder in developed countries, with the associated clinical complications driven by portal hypertension (PH). PH may precede fibrosis development, probably due to endothelial dysfunction at early stages of the disease. Our aim was to characterize liver sinusoidal endothelial cell (LSEC) dedifferentiation/capillarization and its contribution to PH in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diet, High-Fat
Share to Dietary Carbohydrates

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydroxymethylglutaryl-CoA Reductase Inhibitors

Share to Hypertension, Portal

Share to Non-alcoholic Fatty Liver Disease

Share to Rats, Sprague-Dawley

Source

Open in PubMed Open full text

Identifiers

PMID: 31882668
DOI: 10.1038/s41598-019-56366-2
PMCID: PMC6934751

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Restoration of liver sinusoidal cell phenotypes by statins improves portal hypertension and histology in rats with NASH.PMID 31882668Read ↗

Cilostazol Preserves Central Sinusoidal Endothelium and Attenuates Fibrosis in a Diabetic Steatohepatitis ModelSemantic proximity Read ↗

GTX-11 improves portal hypertension, liver fibrosis, and sinusoidal cells phenotype in experimental MASHSemantic proximity Read ↗

Liver Sinusoidal Endothelial Cells in the Regulation of Immune Responses and Fibrosis in MASH Liver DiseaseSemantic proximity Read ↗

SECs (Sinusoidal Endothelial Cells), Liver Microenvironment, and Fibrosis.Semantic proximity Read ↗

Role of differentiation of liver sinusoidal endothelial cells in progression and regression of hepatic fibrosis in rats.Semantic proximity Read ↗

RISING STARS: Liver sinusoidal endothelial transcription factors in metabolic homeostasis and diseaseSemantic proximity Read ↗

Single-cell transcriptome reveals a novel mechanism of C-Kit+-liver sinusoidal endothelial cells in NASHSemantic proximity Read ↗

Phenotypical and morphological alterations to rat sinusoidal endothelial cells in arterialized livers after portal branch ligation.Semantic proximity Read ↗

An LSEC-focused computational drug repurposing platform for liver fibrosis: Identification of vorinostat and other LSEC-protective candidatesSemantic proximity Read ↗

Sex-specific differences in preclinical models of advanced chronic liver disease and portal hypertensionSemantic proximity Read ↗

Hepatic Arterial Flow-Induced Portal Tract Fibrosis in Portal Hypertension: The Role of VCAM-1 and Osteopontin-Expressing MacrophagesSemantic proximity Read ↗

The evolving role of liver sinusoidal endothelial cells in liver health and diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.